Elucidating the mechanism of cellular uptake and removal
Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China Received 25 September 2014; Accepted 11 January 2015Academic Editor: Karsten Weylandt Copyright © 2015 Yue Wang and Feiruo Huang.
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Some of the effects of n-3 PUFA are brought about by regulation of gene expression through interacting with nuclear receptors and transcription factors; other effects are elicited by modulation of the amount and type of mediator derived from PUFAs.
Properties leading to the susceptibility of nervous tissue include a high surface area of neurons, a high lipid content which retains lipophilic toxins, high blood flow to the brain inducing increased effective toxin exposure, and the persistence of neurons through an individual's lifetime, leading to compounding of damages.Toxicology ranges from basic research investigations on the mechanism of action of toxic agents through the development and interpretation of standard tests characterizing the toxic properties of agents.Toxicology provides important information for both medicine and epidemiology in understanding aetiology and in providing information as to the plausibility of observed associations between exposures, including occupations, and disease.Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations.Neurotoxins inhibit neuron control over ion concentrations across the cell membrane, Additionally, neurotoxin-mediated peripheral nervous system damage such as neuropathy or myopathy is common.
There are mounting evidences demonstrating that obesity and associated disorders pose a daunting threat on global public health problem, given their morbidity and mortality.